Cover Article Publication in International Journal / Department of Bio and Fermentation Convergence Technology Students
Identifying Clinical Heterogeneity Using Single Extracellular Vesicle Multi-modal Analysis Technology
- 26.02.13 / 전윤실
A research project involving undergraduate students from the Department of Convergence Bioengineering at Kookmin University (President Jeong Seung Ryul) has been published in the globally renowned journal ACS Applied Bio Materials, published by the American Chemical Society, and simultaneously selected as a cover article.
The published paper, titled “Multi-modal single Extracellular vesicle profiling technologies to unveil clinical heterogeneity,” is a review article comprehensively summarizing multi-modal analysis technologies at the single Extracellular Vesicle (EV) level. EVs play a crucial role in disease diagnosis, prognosis prediction, and treatment strategy development.
EVs contain diverse molecular information, including proteins, transcriptomes, and metabolites, making them a promising next-generation liquid biopsy biomarker. However, EVs in bodily fluids inherently possess heterogeneity due to their diverse cellular origins, limiting their clinical utility. To address these challenges, the research team systematically analyzed emerging single EV profiling technologies. They presented the latest research trends and technical development directions for multi-omics-based analysis platforms. These platforms go beyond conventional qualitative and semi-quantitative surface protein analysis to enable digital quantification of surface proteins, detection of internal transcripts, and simultaneous analysis of surface proteins and internal transcripts.
This research involved undergraduate students Kwon Yu Jin (first author), Kim Hye Min (co-author), and Kwon Hyun (co-author) from the Department of Bio and Fermentation Convergence Technology and was conducted under the guidance of Professor Park Ju Hwan. Notably, student Kwon Yu Jin led the entire process—from literature review and technical analysis to manuscript writing—earning her position as first author. This achievement is considered highly exceptional, as it marks the rare instance of an undergraduate student serving as first author on a cover paper in a prestigious international journal.
Above all, this research was supported by the Bio-Specialized University Support Project (Bio-Pharmaceutical Production Process Specialization Talent Development Project Team, led by Professor Oh Sang Taek) under the Department of Bio and Fermentation Convergence Technology at Kookmin University. It holds significant meaning as the fruit of a systematic research education program that supports students in experiencing the entire process—from research planning and execution to paper writing—starting at the undergraduate level.
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This content is translated from Korean to English using the AI translation service DeepL and may contain translation errors such as jargon/pronouns. If you find any, please send your feedback to kookminpr@kookmin.ac.kr so we can correct them.
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Cover Article Publication in International Journal / Department of Bio and Fermentation Convergence Technology Students Identifying Clinical Heterogeneity Using Single Extracellular Vesicle Multi-modal Analysis Technology |
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A research project involving undergraduate students from the Department of Convergence Bioengineering at Kookmin University (President Jeong Seung Ryul) has been published in the globally renowned journal ACS Applied Bio Materials, published by the American Chemical Society, and simultaneously selected as a cover article.
The published paper, titled “Multi-modal single Extracellular vesicle profiling technologies to unveil clinical heterogeneity,” is a review article comprehensively summarizing multi-modal analysis technologies at the single Extracellular Vesicle (EV) level. EVs play a crucial role in disease diagnosis, prognosis prediction, and treatment strategy development.
EVs contain diverse molecular information, including proteins, transcriptomes, and metabolites, making them a promising next-generation liquid biopsy biomarker. However, EVs in bodily fluids inherently possess heterogeneity due to their diverse cellular origins, limiting their clinical utility. To address these challenges, the research team systematically analyzed emerging single EV profiling technologies. They presented the latest research trends and technical development directions for multi-omics-based analysis platforms. These platforms go beyond conventional qualitative and semi-quantitative surface protein analysis to enable digital quantification of surface proteins, detection of internal transcripts, and simultaneous analysis of surface proteins and internal transcripts.
This research involved undergraduate students Kwon Yu Jin (first author), Kim Hye Min (co-author), and Kwon Hyun (co-author) from the Department of Bio and Fermentation Convergence Technology and was conducted under the guidance of Professor Park Ju Hwan. Notably, student Kwon Yu Jin led the entire process—from literature review and technical analysis to manuscript writing—earning her position as first author. This achievement is considered highly exceptional, as it marks the rare instance of an undergraduate student serving as first author on a cover paper in a prestigious international journal.
Above all, this research was supported by the Bio-Specialized University Support Project (Bio-Pharmaceutical Production Process Specialization Talent Development Project Team, led by Professor Oh Sang Taek) under the Department of Bio and Fermentation Convergence Technology at Kookmin University. It holds significant meaning as the fruit of a systematic research education program that supports students in experiencing the entire process—from research planning and execution to paper writing—starting at the undergraduate level.
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